Figure S1 a-c: Pedigrees from families carrying 16 CHEK2variants discussed
Filled symbol, cancer confirmed by pathologist report; partially filled
symbol, cancer referred by relative; arrow, index case. Cosegregation
results are indicated with the name of the variant if present and WT for
non-carriers. Current ages and ages at death, when available, are
indicated on the top-left corner of each individual’s symbol. BC, breast
cancer; BlC, bladder cancer; BrC, brain cancer; CRC, colorectal cancer;
EC, endometrial cancer GC, gastric cancer; HFN, head/face/neck cancer;
KC, kidney cancer; LC, lung cancer; Leu, leukemia; LiC, Liver cancer;
Lym, Lymphoma; OC, ovarian cancer; PC, pancreas cancer; Para,
parathyroid cancer; PCC, pheochromocytoma; PrC, prostate cancer; SC,
skin cancer; SA, sebaceous adenoma; SAR, sarcoma; T, thyroid cancer;
TeC, testicular cancer.