Study
Design
Disease
Age (range, years) Therapy in experimental group
Therapy in control group
Dosage
Sample size
Sample size
NE sample size
NE sample size
NE type and sample size Followup period (wk)
Experimental Control Experimental Control
Jonathan 1998
RCT
asthma
15 to 45 years
Montelukast
Placebo
10mg
54
56
11
18
Headache11/18
12
Knorr 1998
RCT
asthma
6- 14-years
Montelukast
Placebo
5mg
201
135
38
29
Headache38/29
8
Noonan 1998
RCT
asthma
18–65 yrears
Montelukast
Placebo
2mg/10mg/50mg
212
69
18
10
18/10
3
Theodore 1998 RCT asthma ≥15 years Montelukast Placebo 10mg 408 273 75 61 Headache73/57;depression1/4;anxiety1/0 12
Malmstrom 1999 RCT asthma ≥15 years Montelukast Placebo 10mg 387 257 68 40 Headache68/40 12
Meltzer 2000-1
RCT
Allergic rhinitis
15 - 75 years
Montelukast
Placebo
10mg
185
91
12
6
Headache12/6
2
Meltzer 2000-2
RCT
Allergic rhinitis
15 - 75 years
Montelukast/ Loratadine
Loratadine
10mg+10mg:10mg
90
92
1
8
Headache1/8
2
Anjuli 2002-1
RCT
Allergic rhinitis
15 - 85 years
Montelukast
placebo
10mg
155
149
5
7
Headache5/7
2
Anjuli 2002-2
RCT
Allergic rhinitis
15 - 85 years
Montelukast/ Loratadine
Loratadine
10mg+10mg:10mg
302
301
9
12
Headache9/12
2
Baumgartner 2003 RCT asthma ≥15 years Montelukast Placebo 10mg 313 103 31 18 Headache31/18 6
CarlosE 2003
RCT
Allergic rhinitis and asthma
≥15 years
Montelukast
Placebo
10mg
311
302
11
11
Headache11/11
4
YildirimI 2004 RCT asthma mean:36.93 ± 2.98 years Montelukast/Budesonide Budesonide 10mg+400 mg:800mg 15 15 2 0 Headache2/0 6
Charles 2006
RCT
asthma
≥15 years
Montelukast
Placebo
10mg
164
164
34
36
nervousness34/36
24
Shah 2006
RCT
asthma
18 - 60 years
Montelukast/Budesonide
Budesonide
10mg+200mg:400mg
30
30
1
0
Headache1/0
8
Bisgaard 2009
RCT
Allergic rhinitis
2-14 years
Montelukast
Placebo
5mg
280
133
9
2
Headache9/2
8
Bruce 2010-1
RCT
asthma
15 - 92 years
Montelukast
Placebo
10mg or 20mg
555
1111
6
19
Headache6/19
2
Bruce 2010-2
RCT
asthma
15 - 92 years
Montelukast/ Loratadine
Loratadine
10mg+10mg:10mg
969
971
66
85
Nervous system disorders66/85; Headache34/29; Somnolence25/10
2