The manuscript aims to describe the effect of COVID-19 virus on the patients suffering with neurological diseases. The outbreak of COVID-19 is serious and it becomes epidemic worldwide. It is observed from the literature survey that COVID-19 virus can easily affect the persons having neurological diseases. The manuscript also focuses on the mechanism of action of the COVID-19 virus on the nervous system with precaution majors. Patients with COVID-19 show various symptoms of neurological manifestations including stroke, impaired consciousness, seizures, agitation, unsteadiness, dizziness, confusion, localized neuralgia and cognitive impairment. The COVID-19 virus affect the Central Nervous System, makes the patients clinical condition worse and it may cause the death of the patient. It can be concluded from the literatures that COVID-19 virus versen the neurological condition of patients and may leads to severe manifestations.