Discussion:
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the dysregulated production of mature and maturing granulocytes with normal differentiation, and it is associated with the fusion of two genes: BCR (on chromosome 22) and ABL1 (on chromosome 9) resulting in the BCR-ABL1 fusion gene. That gives rise to an abnormal chromosome 22 called the Philadelphia (Ph) chromosome. CML has three phases which included; chronic phase, accelerated phase and blast phase [4].
It is well known in the literature some viral infections increases the risk of some hematological malignancy Epstein-Barr virus the risk of Burkitt lymphoma, and non-Hodgkin’s lymphoma and human T-lymphotrophic virus (HTLV-1) which increase the risk of adult T-cell leukemia/lymphoma[5] but so far the exact mechanism of cancer development after viral infection is not well understood. Up to our knowledge there is no viral infection was proven to increases risk of CML.
Since the discovery of COVID 19 it has been reported in the literate to be associated with other diseases at time of presentation like association with acute ST elevation myocardial infarction[6], and the association with neurological diseases like meningitis and encephalitis [7], also it was reported with Guillain-Barré Syndrome[8].In Our case the presentation of COVID 19 was associated with CML at the time of presentation and up to our knowledge this is the first of such association; however this association could be only a coincidence.