Figure captions
Figure 1. Metformin and Rapamycin could decrease the incidence
of age-related diseases. In terms of mechanism, metformin and rapamycin
achieve similar calorie restriction effect in different ways. Metformin
can activate AMPK like calorie restriction and further cause a series of
pathways changes, which could arouse anti-aging effects such as
Inhibition of pro-inflammatory effect and ROS detoxification. Rapamycin
can inhibit mTORC1, which relate to Autophagy and Protein Synthesis
pathway.