Alzheimer’s Disease
The Alzheimer’s Disease (AD) is a degenerative neurological disorder,
accounting for 60-80% of dementia 24. AD affects up
to one third of the population aged > 65 years, making it
the fifth leading cause of death globally 25. Although
causal determinants of AD remain not fully understood, impaired
mitochondrial autophagy (termed mitophagy), the accumulation of
amyloid-β (Aβ plaques) and neurofibrillary tangles (tau),
neuro-inflammation, and altered cerebrovascular reactivity appear to be
the contributors to the pathogenesis of AD 26, 27.