Box 1 Aging-related diseases
Advanced age is the major risk factor for developing multiple chronic diseases 19. In this review, two of the geropreventive medicines, metformin and rapamycin, are discussed with respect to their potential for delaying the age-related diseases that are described in the following sections below. Since age-related diseases is a broad concept that recapitulates a wide range of conditions, including but not limited to sarcopenia, osteoporosis and chronic obstructive pulmonary disease, we here only list age-related diseases whose treatments have been shown by research to benefit from metformin or rapamycin.