Box 1 Aging-related diseases
Advanced age is the major risk factor for developing multiple chronic
diseases 19. In this review, two of the geropreventive
medicines, metformin and rapamycin, are discussed with respect to their
potential for delaying the age-related diseases that are described in
the following sections below. Since age-related diseases is a broad
concept that recapitulates a wide range of conditions, including but not
limited to sarcopenia, osteoporosis and chronic obstructive pulmonary
disease, we here only list age-related diseases whose treatments have
been shown by research to benefit from metformin or rapamycin.