Alzheimer’s Disease
The Alzheimer’s Disease (AD) is a degenerative neurological disorder, accounting for 60-80% of dementia 24. AD affects up to one third of the population aged > 65 years, making it the fifth leading cause of death globally 25. Although causal determinants of AD remain not fully understood, impaired mitochondrial autophagy (termed mitophagy), the accumulation of amyloid-β (Aβ plaques) and neurofibrillary tangles (tau), neuro-inflammation, and altered cerebrovascular reactivity appear to be the contributors to the pathogenesis of AD 26, 27.