Relationship between coronary microvascular dysfunction and left
ventricular diastolic function
In a univariate regression analysis using MBFR as a continuous
independent variable and septal mitral annular E/e’ as a continuous
outcome variable (Table III), no significant association was found
between MBFR and septal mitral annular E/e’ (β=-0.24 95% CI -1.53,
+1.05, p=0.71). Increasing age was the only significant predictor for
increasing septal mitral annular E/e’ (β=+0.19 95% CI +0.12, +0.25,
p=<0.001). Multivariable regression analysis in a model using
known influencers of LV diastolic function (age, sex, diabetes,
hypertension, smoking status, BMI, fasting TG, fasting LDL, MBFR and
Hs-CRP) showed only age was the significant predictor of increasing
septal mitral E/e’ (β=+0.20 95% CI +0.13, +0.28, p<0.001,
r²=0.21) (Table IV).
Sensitivity analysis of the model above was performed instead defining
CMD as a binary independent variable (MBFR<2.0) and septal
mitral annular E/e’ as a continuous outcome variable. No significant
association was found between patients with evidence of CMD with
increasing septal mitral annular E/e’ in the univariate (β=-0.57, p=0.8)
or multivariable regression analysis.