One hundred and eighty-six patients had secretory tumours with a demonstrably elevated tumour marker at diagnosis: alpha-fetoprotein (AFP) in 157 (81.8%), beta-human chorionic gonadotropin (b-HCG) in 28 (14.6%) and oestradiol in one patient (0.5%).  Six patients had an elevated lactate dehydrogenase (LDH) in addition to another elevated tumour marker. Using the same methodology for age, we investigated the hypothesis of the existence of a threshold in the relationship between serum AFP levels at diagnosis and outcome. The analysis suggested negligible or no effect of serum AFP levels on OS or EFS for (relatively) small values of AFP, but a rapid increase of the hazard ratio for high values, such that  serum AFP levels became significant as a prognostic factor for outcome at a serum AFP level ≈ 33,000 ng/ml for OS and a serum AFP level ≈ 21,600 ng/ml for EFS (p=0.044).