Conclusion:
Our findings suggested the vital role of nasal airways epithelial cells in the pathogenesis of asthma by their differential gene expression in different asthma groups. Herein, TMEM178 expression gained attention as a predictor of asthma severity suggesting its significant value in the discrimination between different asthma phenotypes. CLCA1, SERPINB2 and Periostin expression were upregulated in airway epithelial cells of asthmatic children, however; no significant differences between different groups of asthma severity were observed. Regarding to asthma control level, TMEM178, CLCA1, SERPINB2 and Periostin were significantly up regulated in controlled group compared to partially to uncontrolled asthma group. Whereas, FKBP5 was upregulated in partially to uncontrolled asthma group. Regarding to atopic status, CLCA1, SERPINB2 and Periostin were significantly up regulated in atopic than non-atopic asthma while TMEM178 and FKBP5 showed no statistically significant differences between atopic and non-atopic asthma.
V: Acknowledgement: NO