Supplementary Materials
S1 Text . Lists of GO-retrieved WNT signaling genes.
S2 Text . Hispanic gene-based mutational burden analysis results
S3 Text . European Ancestry gene-based mutational burden analysis results
S4 Fig. Calcium WNT pathway . A depiction of PLCB1’s role in the noncanonical Ca2+ WNT signaling pathway. PLCB1 activates the G-protein coupled receptor’s alpha subunit, which is necessary for the downstream activation of CAMK2A.
S5 Text. Hispanic mutational burden analysis variants.Variant data for those variants used in the Hispanic mutational burden analysis which fall within nominally significant disrupted genes.
S6 Text. European ancestry mutational burden analysis variants. Variant data for those variants used in the European ancestry mutational burden analysis which fall within nominally significant disrupted genes.