Results
Time to achieve hemostasis was significantly reduced in the F8 arm [MD -21.04 mins (95% CI: -35.66 to -6.42; p=.005)]. Access site bleeding was significantly lower in the F8 group [RR 0.35 (95% CI: 0.18 to 0.66; p=0.001)] along with a lower incidence of hematoma formation [RR 0.42 (95% CI 0.26 to 0.67; p=0.0003)]. There was no significant difference in rates of fistula or pseudoaneurysm formation between the two groups. Overall access site complications were lower in the F8 arm [RR 0.38 (95% CI: 0.26 to 0.55; p<0.00001)] and the effect was more pronounced for sheaths ≥10 Fr [RR 0.33 (95% CI: 0.18 to 0.60; p=0.0003)]. There was lower post-procedural protamine use in the F8 group [RR 0.07 (95% CI:0.01 to 0.36; p=0.001)].