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Yong Yang
Yong Yang

Public Documents 5
The Chirality of Isotopomers of Glycine Compared using Next-Generation QTAIM
Xing Nie
Yong Yang

Xing Nie

and 5 more

December 08, 2021
The effect of the presence of a deuterium (D) or tritium (T) isotope bonded to the alpha carbon of glycine is determined without the need to apply external forces e.g. electric fields or using normal mode analysis. Isotopic effects were accounted for using the mass-dependent diagonal Born-Oppenheimer energy correction (DBOC) at the CCSD level of theory. We calculated the stress tensor trajectories of the dominant C-N bond within next generation quantum theory of atoms in molecules (NG-QTAIM). S-character chirality was discovered using the stress tensor trajectories, instead of the Cahn–Ingold–Prelog (CIP) rules, for ordinary glycine. The S-character chirality was preserved after the substitution of the H on the alpha carbon for a D isotope but transformed to R-character chirality after replacement with the T isotope. This reversal of the chirality depending on the presence of a single D or T isotope bound to the alpha carbon adds to the debate on the nature of the extraterrestrial origins of chirality in simple amino acids. We demonstrate that NG-QTAIM is a promising tool for understanding isotopic induced electronic charge density changes, useful in analysis of infrared (IR) or circular dichroism (CD) spectra explaining changes in mode couplings and bands intensities or sign.
Control of Chirality, Bond flexing and Anharmonicity in an Electric Field
Zi Li
Xing Nie

Zi Li

and 10 more

June 18, 2021
We located ‘hidden’ S-character chirality in formally achiral glycine using a vector-based interpretation of the total electronic charge density distribution. We induced the formation of stereoisomers in glycine by the application of an electric field. Control of chirality was indicated from the proportionate response to a non-structurally distorting electric field. The bond-flexing was determined to be a measure of bond strain, which could be a factor of three lower or higher, depending on the direction of the electric field, than in the absence of the electric field. The bond-anharmonicity was found to be approximately independent of the electric field. We also compared the formally achiral glycine with the chiral molecules alanine and lactic acid, quantifying the preferences for the S and R stereoisomers. The proportional response of the chiral discrimination to the magnitude and direction of the applied electric field indicated use of the chirality discrimination as a molecular similarity measure.
Defining the Bounds of Chemical Coupling Between Covalent and Hydrogen-bonds in Small...
Zi Li
Yong Yang

Zi Li

and 5 more

July 14, 2021
We seek to determine the two-way transfer of chemical character due to the coupling occurring between hydrogen-bonds and covalent-bonds known to account for the unusual strength of hydrogen-bonds in water. We have provided a vector-based quantification of the chemical character of uncoupled hydrogen-bonds and covalent-bonds and then determined the effects of two-way coupling consistent with the total local energy density H(rb) < 0 for hydrogen-bonds. We have calculated the precessions Kʹ of the eigenvectors around the bond-path for the Ehrenfest Force F(r) and compared with the corresponding QTAIM Kʹ. In doing so we explain why the Ehrenfest Force F(r) provides insights into the coupling between the hydrogen and covalent bonds whilst QTAIM cannot. Conditions for favorable transfer of electron momentum from the hydrogen atom of a sigma bond to the hydrogen-bond are found, with excellent agreement with the hydrogen-bond BCP and covalent-bond BCP separations providing the theoretical bounds for coupling.
Bond Flexing, Twisting, Anharmonicity and Responsivity for the IR-active modes of Ben...
Yong Yang
Tianlv Xu

Yong Yang

and 3 more

October 06, 2020
In this investigation we have used NG-QTAIM to fully quantity the response to the four IR-active modes of all the bonding in benzene in terms of bond-flexing, bond-torsion and bond-anharmonicity that includes the tendencies towards IR-responsivity and IR-non-responsivity. Bond-anharmonicity is found to be lacking for the C-C bonds comprising the lowest frequency mode (721.57 cm-1) measured as the absence of bond critical point (BCP) sliding. Additionally, bond-flexing was absent for this mode harmonic-like variation of the profile of the variation of the wrapping (torsion) of the {p,p’} path-packet, referred to as the Precession K, along the conventional QTAIM bond-path, the remaining three IR-active mode possessed step-like variations in the K profiles. The presence of non-nuclear attractors was detected for the IR-active mode with frequency 1573.93 cm-1 with C-C K profiles that most closely resemble those of the relaxed benzene. We quantified the C-H bonds in terms of bond-flexing and bond-anharmonicity and IR-responsivity and IR-non-responsivity.
Fatigue and Fatigue Resistance in S1 Excited State Diarylethenes in Electric fields
Xing Nie
Yong Yang

Xing Nie

and 4 more

May 18, 2020
The effect of a directional electric-field on the bonding of the undoped and sulphur doped diarylethene (DTE) switch molecule is investigated using next generation QTAIM (NG-QTAIM). We introduce chemical bonding concepts in the form of the least and most preferred directions of charge density accumulation relative to the associated bond-path, namely the precessions K and Kʹ that are demonstrated to be much more responsive to the electric-field than the Laplacian ∇2ρ(rb). A concept of bond fatigue is presented in terms of the tendency for a bond-path to rupture that provides directional versions of familiar bonding QTAIM concepts. Examples are included where the applied directional electric-field reduces the tendency towards bond-path rupture and also the converse. A brief discussion is undertaken of applications of the precessions K and Kʹ including switches, ring opening reactions and molecular rotary motors in the presence of fields that cause a redistribution of ρ(r).
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