FigureĀ 1 The role of aspirin to tumor angiogenesis
inhibition by regulation a balance of endogenous inhibitors andstimulators. (A) In the
tumor microenvironment, the sum effect of these inhibitors and
stimulants is angiogenesis with abnormal structure and function. This
imbalance proangiogenic effects is aggravated by activated platelets,
monocytes and macrophages. (B) Aspirin may reverse the balance of
antiangiogenic and proangiogenic effect in angiogenesis through lower
endogenous stimulators and boost inhibitors. Reverse of antiangiogenic
and proangiogenic balance may inhibit angiogenesis, normalize existing
blood vessels and reduce permeability and leakiness.
Abbreviations: TSP-1, thrombospondin-1; ZO-1, Zonula Occludens-1; VEGF,
Vascular endothelial growth factor; FGF, Fibroblast growth factor; MMPs,
matrix metalloproteinases; mTOR,
Mammalian target of rapamycin.