Author contributions
F.L. conceived and designed the whole project; Z.H. improved the work; L. C. and K. L. wrote the program and did the assay with RNA-Seq data. Y. M. and Z. S. constructed the webserver of FastD; K. H. and H. X. participate the discussion; L. C drafted the manuscript. H.X. and F. L. improved and finalized the manuscript. All authors approved the final manuscript.