Systematic Procedure for Optimization Problem
Formulation
Figure 2 shows the 3-step procedure. In Step 1, the cosmetic formulation
problem is defined where the desired product form, product attributes,
and product specifications and properties are determined based on market
study and product knowledge. In Step 2, potential ingredient candidates
and relevant microstructural descriptors (if applicable) are generated
to specify the design variables. Step 3 identifies a set of mechanistic
models and surrogate models and converts heuristics into mathematical
equations. For each step, the sources of the input are shown on the left
and the outputs are on the right. The details are described below.