Table and Figure legends
Table 1 Characteristics of GD patients and controls in this study.
Table 2 Association between IL2RA / rs3118470/ rs2104286 polymorphisms and GD susceptibility.
Table 3 Allele and genotype frequencies of three candidate gene loci and
susceptibility to GO.
Figure 1 The IL2RA mRNA expression in anti-CD3/CD28 antibodies-stimulated PBMCs from healthy controls carrying various genotypes of rs2104286 (GG: N=11, AG: N=12, AA: N=12). The data are presented as the mean±SD.
Figure 2 The influence of various rs3118470 genotypes on the IL-6 (A), IL-10 (B), IL-17(C) and TGF-β1(D) production (GG: N=12, AG: N=12, AA: N=12). The production of cytokine was quantified by ELISA in PBMCs,which were obtained from healthy controls with various rs3118470genotypes and treated with anti-CD3/CD28 antibodies.
Figure 3 The influence of various rs2104286 genotypes on the IL-6 (A), IL-10 (B), IL-17(C) and TGF-β1(D) production (GG: N=11, AG: N=12, AA: N=12). The production of cytokine was quantified by ELISA in PBMCs, which were obtained from healthy controls with various rs3118470 genotypes and treated with anti-CD3/CD28 antibodies.
Table S1 PCR primer sequences and reaction condition in this study.
Table S2 Association between remaining seven SNP polymorphisms and GD susceptibility.
Figure S1 The IL2RA mRNA expression difference with rs3118470 locus various genotype individuals.