Table and Figure legends
Table 1 Characteristics of GD patients and controls in this
study.
Table 2 Association between IL2RA / rs3118470/ rs2104286
polymorphisms and GD susceptibility.
Table 3 Allele and genotype frequencies of three candidate gene
loci and
susceptibility to GO.
Figure 1 The IL2RA mRNA expression in anti-CD3/CD28
antibodies-stimulated PBMCs from healthy controls carrying various
genotypes of rs2104286 (GG: N=11,
AG: N=12, AA: N=12). The data are presented as the mean±SD.
Figure 2 The influence of various
rs3118470 genotypes on the IL-6
(A), IL-10 (B), IL-17(C) and TGF-β1(D) production (GG: N=12, AG: N=12,
AA: N=12).
The
production of cytokine was quantified by ELISA in PBMCs,which were
obtained from healthy controls with various rs3118470genotypes and
treated with anti-CD3/CD28 antibodies.
Figure 3 The influence of various rs2104286 genotypes on the
IL-6 (A), IL-10 (B), IL-17(C) and TGF-β1(D) production (GG: N=11, AG:
N=12, AA: N=12). The production of cytokine was quantified by ELISA in
PBMCs, which were obtained from healthy controls with various rs3118470
genotypes and treated with anti-CD3/CD28 antibodies.
Table S1 PCR primer sequences and reaction condition in this
study.
Table S2 Association between remaining seven SNP polymorphisms
and GD susceptibility.
Figure S1 The IL2RA mRNA expression difference with
rs3118470 locus various genotype individuals.