Allele and genotype frequencies in GO patients and controls
To further verify the relationship between the three candidate genes and susceptibility to GO, we performed a hierarchical analysis. The results showed that the IL2RA /rs3118470 T allele and the TT genotype showed increased frequencies in GO patients than in controls (T allele:Pc = 4.036 × 10-4, OR = 1.612; TT genotype: Pc = 1.848 × 10-6, OR = 2.178), whereas the C allele and the CT genotype showed decreased frequencies in GO patients (C allele: Pc = 4.036 × 10-4,OR = 0.620; CT genotype: Pc = 0.018, OR = 0.628). TheIL2RA /rs2104286 AA genotype showed an increased frequency in GO patients than in controls (Pc = 1.230 × 10-3,OR = 1.851), while the AG genotype showed a decreased frequency in GO patients (Pc = 9.420 × 10-6, OR = 0.348; Table 3).