SNPs
|
Stage
|
Allele
/Genotype
|
GD
patients (%)
|
Healthy
controls (%)
|
P value
|
Pc value
|
OR (95% CI)
|
rs3118470 |
First |
C |
262(43.667) |
611(51.002) |
0.004 |
NS |
0.745(0.611-0.907) |
(IL2RA) |
|
T |
338(56.333) |
587(48.998) |
0.004 |
NS |
1.343(1.103-1.635) |
|
|
CC |
72(24.000) |
165(27.546) |
0.262 |
NS |
0.831(0.603-1.14) |
|
|
CT |
118(39.333) |
281(46.912) |
0.033 |
NS |
0.734(0.554-0.973) |
|
|
TT |
110(36.667) |
153(25.543) |
0.001 |
0.027* |
1.688(1.253-2.274) |
|
Second |
C |
299(44.627) |
682(49.636) |
0.033 |
NS |
0.818(0.679-0.984) |
|
|
T |
371(55.373) |
692(50.364) |
0.033 |
NS |
1.223(1.016-1.472) |
|
|
CC |
69(20.597) |
177(25.764) |
0.070 |
NS |
0.747(0.545-1.024) |
|
|
CT |
161(48.060) |
328(47.744) |
0.924 |
NS |
1.013(0.780-1.315) |
|
|
TT |
105(31.343) |
182(26.492) |
0.105 |
NS |
1.267(0.951-1.687) |
|
Combined |
C |
561(44.173) |
1293(50.272) |
3.725×10-4
|
1.490×10-3
|
0.783(0.684-0.896) |
|
|
T |
709(55.827) |
1279(49.728) |
3.725×10-4
|
1.490×10-3
|
1.278(1.116-1.462) |
|
|
CC |
141(22.205) |
342(26.594) |
0.037 |
NS |
0.788(0.630-0.986) |
|
|
CT |
279(43.937) |
609(47.356) |
0.157 |
NS |
0.871(0.720-1.055) |
|
|
TT |
215(33.858) |
335(26.050) |
3.687×10-4
|
2.212×10-3
|
1.453(1.182-1.786) |
rs2104286 |
First |
A |
505(84.167) |
952(79.333) |
0.015 |
NS |
1.385(1.068-1.796) |
(IL2RA) |
|
G |
95(15.833) |
248(20.667) |
0.015 |
NS |
0.722(0.557-0.936) |
|
|
AA |
224(74.667) |
384(64.000) |
0.001 |
0.027* |
1.658(1.217-2.258) |
|
|
AG |
57(19.000) |
184(30.667) |
1.710×10-4
|
4.617×10-3*
|
0.530(0.379-0.745) |
|
|
GG |
19(6.333) |
32(5.333) |
0.543 |
NS |
1.200(0.668-2.155) |
|
Second |
A |
569(81.988) |
1094(78.143) |
0.040 |
NS |
1.273(1.010-1.605) |
|
|
G |
125(18.012) |
306(21.857) |
0.040 |
NS |
0.785(0.623-0.990) |
|
|
AA |
250(72.046) |
430(61.429) |
0.001 |
0.006 |
1.618(1.224-2.140) |
|
|
AG |
69(19.885) |
234(33.429) |
5.389×10-6
|
3.233×10-5
|
0.494(0.364-0.672) |
|
|
GG |
28(8.069) |
36(5.143) |
0.063 |
NS |
1.619(0.971-2.700) |
|
Combined |
A |
1074(82.998) |
2046(78.692) |
0.002 |
0.008 |
1.322(1.112-1.571) |
|
|
G |
220(17.002) |
554(21.308) |
0.002 |
0.008 |
0.757(0.636-0.899) |
|
|
AA |
474(73.261) |
814(62.615) |
2.924×10-6
|
1.754×10-5
|
1.636(1.330-2.012) |
|
|
AG |
126(19.474) |
418(32.154) |
4.274×10-9
|
2.564×10-8
|
0.510(0.407-0.640) |
|
|
GG |
47(7.264) |
68(5.230) |
0.073 |
NS |
1.419(0.966-2.084) |