Allele and genotype frequencies of nine SNPs in the first phase study
In the first phase, association between nine SNPs in four genes (IL2RA , miR27a , miR182, and FoxO1 ) and susceptibility to GD were investigated in 300 GD cases and 600 healthy controls. Our analysis revealed a correlation of theIL2RA /rs3118470 TT genotype with increased GD risk (TT genotype:Pc = 0.027, OR = 1.688). For the IL2RA /rs2104286 locus, subjects carrying the AA genotype had higher susceptibility to GD (Pc = 0.027, OR = 1.658), while the AG genotype protected against GD (Pc = 4.617 × 10-3, OR = 0.530 (Table 2). No association was identified between the remaining seven SNPs (rs7093069, rs895819, rs76481776, rs2297626, rs17592236, rs9549241, and rs12585277) and susceptibility to GD (P > 0.05; Table S2).