Conclusions:
Sickle Cell Disease can be very challenging during cardiopulmonary bypass. Vaso-occlusive crises can be triggered by hypoxia, hypothermia, acidosis, or low-flow states. Exchange transfusion can reduce HbS, and increase hematocrit level, this will facilitate a better oxygen delivery. Mild hypothermia can be used if sufficient CPB flows are maintained at a minimum cardiac index of 2.4 L/min and venous saturation is kept more than 70%.