Conclusions:
Sickle Cell Disease can be very challenging during cardiopulmonary
bypass. Vaso-occlusive crises can be triggered by hypoxia, hypothermia,
acidosis, or low-flow states. Exchange transfusion can reduce HbS, and
increase hematocrit level, this will facilitate a better oxygen
delivery. Mild hypothermia can be used if sufficient CPB flows are
maintained at a minimum cardiac index of 2.4 L/min and venous saturation
is kept more than 70%.