Chemokines |
Origin |
Function |
TARC/CCL17 (CC chemokine)
thymus and activation-regulated chemokine
CCR4, CCR8 receptor
|
secreted from monocytes, dendritic and epithelial cells (19)
|
attracts T lymphocytes (Th2)
|
PARC/CCL18 (CC chemokine)
pulmonary and activation- regulated chemokine
CCR8 receptor (38)
|
secreted from antigen-presenting cells, mast cells, eosinophils and
neutrophils (39)
|
attracts naive CD4+ and CD8+ T
cells, B cells, and immature dendritic cells (38, 40)
|
Eotaxin-1/CCL11 (CC chemokine)
eosinophil chemotactic protein
CCR3 receptor
|
secreted from eosinophils (41)
|
attracts eosinophils (42), selective on CCR3 receptor (24)
|
MCP-3/CCL7 (CC chemokine)
monocyte chemotactic protein-3
CCR1, CCR3 receptor
|
secreted from mononuclear cells (43)
|
attracts monocytes, dendritic cells, lymphocytes, natural killer cells,
eosinophils, basophils and neutrophils (44)
|
MIP1α/CCL3 (CC chemokine)
macrophage inflammatory protein-1α
CCR1, CCR5 receptors
|
secreted from T- and B-lymphocytes, neutrophils, dendritic cells, mast
cells and NK cells (34)
|
attracts IFNγ-activated neutrophils and only small subpopulations of
CCR1 expressing eosinophils (34)
|
ENA-78/CCL5 (CXC chemokine)
the epithelial cell-derived neutrophil-activating peptide CXCR2
receptor
|
secreted from monocytes, endothelial cells, mast cells, keratinocytes,
fibroblasts (45, 46)
|
attracts neutrophils (47)
|
IP-10 /CXCL10 (CC chemokine) IFNγ-inducible protein 10
CXCR3 receptor
|
secreted from monocytes, T-lymphocytes, fibroblasts, keratinocytes (48)
in response to the Th1 cytokine IFNγ
|
attracts activated Th1 lymphocytes (49)
|