Chemokines Origin Function
TARC/CCL17 (CC chemokine) thymus and activation-regulated chemokine CCR4, CCR8 receptor
secreted from monocytes, dendritic and epithelial cells (19)
attracts T lymphocytes (Th2)
PARC/CCL18 (CC chemokine) pulmonary and activation- regulated chemokine CCR8 receptor (38) secreted from antigen-presenting cells, mast cells, eosinophils and neutrophils (39) attracts naive CD4+ and CD8+ T cells, B cells, and immature dendritic cells (38, 40)
Eotaxin-1/CCL11 (CC chemokine) eosinophil chemotactic protein CCR3 receptor secreted from eosinophils (41) attracts eosinophils (42), selective on CCR3 receptor (24)
MCP-3/CCL7 (CC chemokine) monocyte chemotactic protein-3 CCR1, CCR3 receptor secreted from mononuclear cells (43) attracts monocytes, dendritic cells, lymphocytes, natural killer cells, eosinophils, basophils and neutrophils (44)
MIP1α/CCL3 (CC chemokine) macrophage inflammatory protein-1α CCR1, CCR5 receptors secreted from T- and B-lymphocytes, neutrophils, dendritic cells, mast cells and NK cells (34) attracts IFNγ-activated neutrophils and only small subpopulations of CCR1 expressing eosinophils (34)
ENA-78/CCL5 (CXC chemokine) the epithelial cell-derived neutrophil-activating peptide CXCR2 receptor secreted from monocytes, endothelial cells, mast cells, keratinocytes, fibroblasts (45, 46) attracts neutrophils (47)
IP-10 /CXCL10 (CC chemokine) IFNγ-inducible protein 10 CXCR3 receptor secreted from monocytes, T-lymphocytes, fibroblasts, keratinocytes (48) in response to the Th1 cytokine IFNγ attracts activated Th1 lymphocytes (49)