Objectives: The aim of this study is to evaluate the hematologic parameters and peripheral blood cell morphological changes in children with COVID-19 and compare them with those of children suspected but then confirmed to be negative for SARS-CoV-2. Methods: Thirty children were tested to be positive for SARS-CoV-2 and the remaining 40 were negative. Hemoglobin, leukocyte, neutrophil, lymphocyte, monocyte counts according to age-specific intervals, platelet, large unstained cell counts, and delta neutrophil index were recorded. Differential counts were formulated by manual counting and morphology of the blood cells were evaluated. Results: The mean leukocyte counts of the SARS-CoV-2 positive and negative groups were 7.0 ± 3.7x109/L and 10.4 ± 7.1x109/L, respectively (p<0.05). Nine (30%) children with COVID-19 had lymphopenia. Among children with COVID-19, absolute lymphocyte count was lower in those with pneumonia (p<0.05). Reactive lymphocytes were noted in 77.8% and 90% in the SARS-CoV-2 test positive and negative groups, respectively (p>0.05). Mean absolute neutrophil counts of the SARS-CoV-2 test positive and negative groups were 3.7±2.9 x109/L and 5.4±4.2 x109/L (p<0.05). Four patients (13.3%) with SARS-CoV-2 test positive had neutrophilia and seven (23.3%) had mild neutropenia. In the peripheral smear, vacuolated monocytes and dysplastic changes in neutrophils and platelets were noted in both groups. Conclusions: Leukocyte, neutrophil and monocyte counts were significantly lower in children with COVID-19 compared with symptomatic children without COVID-19. Lymphopenia, reactive lymphocytosis and dysplasia, could be noted in children with COVID-19. Further studies on hematological findings linked with the course of the disease in children are warranted.
COVID-19 in a child with severe aplastic anemiaYunus Murat Akçabelen1, Ayça Koca Yozgat1, Aslı Nur Parlakay2, Nese Yarali11 Department of Pediatric Hematology, Ankara City Hospital Children’s Hospital, Turkiye2 Department of Pediatric Infectious Disease, Ankara City Hospital Children’s Hospital, TurkiyeArticle type: Letter to the editörRunning Title: COVID-19 in pediatric aplastic anemiaKey words: COVID-19, children, aplastic anemiaDisclosures: noneWord counts: 625