Patients
We prospectively evaluated patients with symptoms suggestive of DHRs to
NSAIDs who had been referred to the Allergy unit of the Hospital
Regional Universitario de Málaga (Málaga), Hospital Clínic (Barcelona),
Hospital Universitario Fundación Alcorcón (Madrid), and Hospital
Regional Universitario de Ciudad Real (Ciudad Real) for a period of 13
years (2005-2018).
Inclusion criteria. Patients ≥14 years-old confirmed as having
DHRs to APs.
Exclusion criteria. Patients <14 years-old; patients in
whom the allergological study was not completed and therefore diagnosis
as either DHRs or tolerant to NSAIDs could not be confirmed: pregnant or
breastfeeding patients; patients taking beta-blockers or ACE inhibitors
or with contraindications for epinephrine administration; patients who
had acute infections and/or underlying cardiac, hepatic, or renal
diseases that contraindicated DPTs; subjects with psychosomatic
disorders; and subjects who refused the study.