The criteria of diagnostic, treatment and discharge
The criteria of diagnostic, treatment and discharge were recommended by the standards published by National Health Commission of the People’s Republic of China[14 15]. The definite diagnosis was made by upon the suspected case, having continuous Positive-Realtime PCR confirmation of COVID-19 with an interval more than 24h in respiratory samples (sputum or throat swabs) monitored by Wenzhou CDC and were reconfirmed by Zhejiang CDC. Classification: Light, had fever respiratory symptom with pneumonia checked by imaging; Severe, satisfied any of the following, respiratory distress, RR ≥ 30 times per min, oxygen saturation ≤ 93% or OI (PaO2/ FiO2) ≤ 300mmHg (1mmHg=0.133kPa); Critical, satisfied any of following, respiratory failure developed, and mechanical ventilation was required, shocked or combined with other organ failure that need ICU care unit. The patients were treated with supporting treatment, isolation ward, rest informed, more water taken, oxygen therapy, strengthen rehydration, correct electrolyte imbalance, close observation and triple antivirus therapy: recombinant human interferon infusion, Lopinavir/ritonavir (Kaletra), Abidor hydrochloride tablets; Chinese traditional treatment was also used, Lianhua qingwen capsule; and other treatments, like antibiotic, glucocorticoid if needed. The discharge was made by normal temperate lasting more than 3 days, better change of respiratory symptom and continuous tests (more than 24h) of COVID-19 PCR were negative.