Introduction
Coronaviruses are a group of viruses with crown-like spikes on the surface of envelope [1]. Although most of them are common and mild infection, the epidemics of SARS-CoV[2-4] and MERS-CoV [5 6] are still nightmare since 21 century with mortality rates of 10% for SARS-CoV and 37% for MERS-CoV[7 8] . In December 2019, China first reported a cluster of cases of unknown pneumonia in Wuhan, and the people infected may be associated with exposure to Huanan seafood market[9]. A novel coronavirus was identified as the pathogen of this outbreak, termed as COVID-19 by the WHO[10]. The epidemics of COVID-19 soon spread to the whole country and cases were reported in other 18 countries make it finally a public health emergency with international concern over global outbreak [11]. However, phyloepidemiologic analyses indicated the SARS-CoV-2 source in China should be imported from other places[12]. So far, the original source has still not been found, than 2.4 million confirmed cases and more than 163000 deaths have been confirmed[13] (reported by WHO, April 22nd,2020).
Wenzhou, a city outside Hubei, has been one of top 10 cities of most cases reported in China since COVID-19 outbroke. To help further understand the novel coronavirus COVID-19 infection and treatment, we describe the clinical features of 64 cases infected by COVID-19 in multi-center in Wenzhou (Data accessed till March 4th). In our studies, we found several characterize features have the correlation to the disease severity, which could be good biomarkers to monitor the disease progress.