The criteria of diagnostic, treatment and discharge
The criteria of diagnostic, treatment and discharge were recommended by
the standards published by National Health Commission of the People’s
Republic of China[14 15]. The definite diagnosis was made by upon
the suspected case, having continuous Positive-Realtime PCR confirmation
of COVID-19 with an interval more than 24h in respiratory samples
(sputum or throat swabs) monitored by Wenzhou CDC and were reconfirmed
by Zhejiang CDC. Classification: Light, had fever respiratory symptom
with pneumonia checked by imaging; Severe, satisfied any of the
following, respiratory distress, RR ≥ 30 times per min, oxygen
saturation ≤ 93% or OI (PaO2/ FiO2) ≤ 300mmHg (1mmHg=0.133kPa);
Critical, satisfied any of following, respiratory failure developed, and
mechanical ventilation was required, shocked or combined with other
organ failure that need ICU care unit. The patients were treated with
supporting treatment, isolation ward, rest informed, more water taken,
oxygen therapy, strengthen rehydration, correct electrolyte imbalance,
close observation and triple antivirus therapy: recombinant human
interferon infusion, Lopinavir/ritonavir (Kaletra), Abidor hydrochloride
tablets; Chinese traditional treatment was also used, Lianhua qingwen
capsule; and other treatments, like antibiotic, glucocorticoid if
needed. The discharge was made by normal temperate lasting more than 3
days, better change of respiratory symptom and continuous tests (more
than 24h) of COVID-19 PCR were negative.