Background: As the COVID-19 became a world wild infectious emergency, most of patients are cured and discharged. However, some patients are re-admitted due to re-fever, or the PCR test re-positive. To find out whether it is necessary to take them re-admitted, especially the asymptomatic patients, we summarize and analyze the clinical and treatment characteristics of patients with “re-admission” of COVID-19 during twice hospitalizations. Methods: 141 cases with COVID-19 admitted to Wenzhou Central Hospital from January 17, 2020 to March 5, were followed up until March 30. There were 12 patients re-admitted. Data were collected, including clinical records，lab indexes，CT and treatment strategy. The differences were analyzed. Results: Most patients had good results. Totally 12 (8.5%) were re-admitted. 1 (8.3%) had fever，high WBC and progressive CT changes，1 had increased transaminase; the PCR re-tests of these two patients were negative. Another 10 patients were admitted due to PCR test positive, 7 of which were clinical asymptomatic. Compared with 1st discharging, CT imaging of all was significantly improved. All re-admissions did not need oxygen inhalation or mechanical ventilation. Conclusions: The prognosis of patients re-admitted were good, and no serious cases. Staying at home or concentrated medical observation, is a safe and feasible method, if the patient has a positive PCR test and the clinical symptoms are not serious. During medical observation, patients with underlying diseases should be focused on, and most do not need to be re-admitted.

Abstract: Background: COVID-19 burst in Wuhan China in December 2019 and soon became a worldwide emergency. To help further understand COVID-19. Here we report the epidemiological, clinical features, potential biomarkers, and CT changes of cases in Wenzhou. Methods:All 64 cases were diagnosed by positive of PCR test. Clinical laboratory tests, CT and treatment were performed in the level 3 of protection. Data and clinical characteristics feature were collected by 4th March. The correlation was analyzed. Results:Most cases were light. The average of latency was 3.4 days, ranged from 1-14. The median age was 44, ranged from 2.2-67; 36 male and 28 female; 59 had fever, 38 with high temperate (>38℃); 45 had respiratory symptoms; 28 had gastrointestinal symptoms; 39 weakness; one asymptomatic case was found. Most with low LC, K+, Na+, OI and high LDH, CRP, D-dimer. Pneumonia, both lungs involvement, ground-glass opacity and consolidation were shown by CTs. Minor had electrocardiography change. Conclusions:The clinical features, abnormality lab indexes and CT characteristics of COVID-19 were like SARS, majored in fever, weakness along with dry cough, diarrhea. LC, LDH could be good biomarkers monitoring progress. The elders, hypertension patients and smokers were more vulnerable. COVID-19 was milder, but more transmissible than SARS. Latency could be up to 14 days without symptoms. CT and PCR shall be both considered in clinical high suspicion. There are still further efforts to be made as to preventing and control the epidemic and the cost in world wild.