Results:
In order to study the role of biomaterials in stem cell differentiation, we analyzed public transcriptomic data sets generated from either microarray or RNA-seq. First, we highlight the importance of biomaterial dimensionality, as we evaluated the effect of 2D versus 3D scaffolds on neural progenitor cell differentiation. Furthermore, we evaluate the impact of biomaterial degradability on the efficiency of stem cell differentiation. Finally, we study how mesenchymal stem cells originated from different pluripotent stem cells result in osteoblasts with different transcriptomic profiles.