Results:
In order to study the role of biomaterials in stem cell differentiation,
we analyzed public transcriptomic data sets generated from either
microarray or RNA-seq. First, we highlight the importance of biomaterial
dimensionality, as we evaluated the effect of 2D versus 3D scaffolds on
neural progenitor cell differentiation. Furthermore, we evaluate the
impact of biomaterial degradability on the efficiency of stem cell
differentiation. Finally, we study how mesenchymal stem cells originated
from different pluripotent stem cells result in osteoblasts with
different transcriptomic profiles.