Main Findings
In this study, we found no statistical difference between the
satisfaction rate of H-E and Papanicolaou stain, both of which could be
used for endometrial cells (45-47). Considering the dyeing degree of
satisfaction, accuracy, predictive value and cost performance, H-E stain
might be a better method than Papanicolaou stain in endometrial
cytology. In the case of a small sample volume of endometrial cells,
Papanicolaou stain is preferred since the cell morphology observed was
superior to H-E stain.
Our study was the first comparison between H-E and Papanicolaou stain in
endometrial cells. By selecting appropriate method according to
different conditions in clinical practice, the diagnostic pressure and
burden of pathologists is relieved. The total cost of endometrial cancer
screening will be reduced. In addition, the early detection and
treatment of endometrial lesions will have a great improvement. At
present, there are few studies on the cost performance of staining which
is important in practical application. The existing researches usually
focused on the dyeing effect only, while ignoring the expenditure that
should be considered in practical application (13, 33-38).
We also combine cost performance and dyeing quality by investigating
price and service time of dye, dyeing efficiency, and dyeing time. We
conclude that H-E stain is a faster and cheaper staining method than
Papanicolaou stain, which could reduce the labor and economic costs
greatly with a broad application prospects under the condition of large
quantities of endometrial cells in clinic practice.