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References:
1 Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. New England Journal of Medicine, doi:10.1056/NEJMoa2021436 (2020).
2 Waterer, G. W. & Rello, J. Steroids and COVID-19: We Need a Precision Approach, Not One Size Fits All. Infect Dis Ther 9, 701-705, doi:10.1007/s40121-020-00338-x (2020).
3 Lanthier, L., Mayette, M., Huard, G., Plourde, M. E. & Cauchon, M. [In patients hospitalized for COVID-19, does dexamethasone reduce 28-days mortality compared to standard treatment?]. Rev Med Interne 41, 790-791, doi:10.1016/j.revmed.2020.08.005 (2020).
4 Russell, C. D., Millar, J. E. & Baillie, J. K. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. The Lancet 395, 473-475, doi:10.1016/S0140-6736(20)30317-2 (2020).
5 Arabi, Y. M. et al. Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome. American Journal of Respiratory and Critical Care Medicine 197, 757-767, doi:10.1164/rccm.201706-1172OC (2017).
6 Ni, Y.-N., Chen, G., Sun, J., Liang, B.-M. & Liang, Z.-A. The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis. Crit Care 23, 99-99, doi:10.1186/s13054-019-2395-8 (2019).
7 Torgerson, D. & Campbell, M. Unequal randomisation can improve the economic efficiency of clinical trials. J Health Serv Res Policy 2, 81-85, doi:10.1177/135581969700200205 (1997).
8 Hey, S. P. & Kimmelman, J. The questionable use of unequal allocation in confirmatory trials. Neurology 82, 77-79, doi:10.1212/01.wnl.0000438226.10353.1c (2014).
9 Kelleni, M. T. Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes. Biomedicine & Pharmacotherapy 133, 110982-110982, doi:10.1016/j.biopha.2020.110982 (2021).
10 Shang, L., Zhao, J., Hu, Y., Du, R. & Cao, B. On the use of corticosteroids for 2019-nCoV pneumonia. The Lancet 395, 683-684, doi:10.1016/S0140-6736(20)30361-5 (2020).
11 Singh, A. K., Majumdar, S., Singh, R. & Misra, A. Role of corticosteroid in the management of COVID-19: A systemic review and a Clinician's perspective. Diabetes & metabolic syndrome 14, 971-978, doi:10.1016/j.dsx.2020.06.054 (2020).
12 Ahmed, M. H. & Hassan, A. Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review. SN Compr Clin Med, 1-10, doi:10.1007/s42399-020-00610-8 (2020).