CL, clearance of the central compartment; V, volume of distribution for the central compartment; k_a, first-order absorption rate constant; F, bioavailability; ω², variance of inter-individual variability; CV, coefficient of variation, calculated as 100* standard errors/ Parameter Value. CI: confidence interval, 2.5th and 97.5th percentile of the ranked bootstrap parameter estimates.

The final model is: CL(L/h)=0.88×(PLT/65)0.32×(TBIL/314)−0.57×exp(ηCL); V(L)=148.8×(WT/58)1.43×exp(ηV); F(%)=88.4