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Evidence for Protein Misfolding in the Presence of Nanoplastics
  • Oldamur Holloczki
Oldamur Holloczki
University of Bonn
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The possible effect of plastic nanoparticles of waste origin on biological systems is still unclear, and could pose a severe threat. Model studies on the molecular level are urgently needed in order to help revealing interplay between these particles biological systems, and thereby to indicate the direction further research. In the present study, simulated annealing molecular dynamics was adjusted and applied to generate an array of conformations for a sample peptide oligoalanine possibly binding to polyethylene and nylon 6,6 nanoplastics. The resulting structures, with a diameter up to 5 nm, were investigated with the aid of static quantum chemical calculations. The obtained data unequivocally show that both plastic nanoparticles influence the relative stability of α-helix, β-hairpin and other conformations strongly. The polyethylene nanoparticle increases the stability of the helical foldamer. The nylon 6,6 nanoplastic offers strong plastic-peptide interactions at its surface, which make the unfolding of the peptide thermodynamically highly favorable. These results further underscore that nanoplastics can do significant, molecular level damage to living organisms via facilitating the misfolding and denaturation of proteins. Furthermore, it is apparent that plastics can have very different effects on living matter depending on their composition, hence experiments with any single kind of plastics (e.g. polystyrene) should not be considered generally valid for all nanoplastics.

01 May 2020Submitted to International Journal of Quantum Chemistry
04 May 2020Submission Checks Completed
04 May 2020Assigned to Editor
19 May 2020Reviewer(s) Assigned
03 Jun 2020Review(s) Completed, Editorial Evaluation Pending
03 Jun 2020Editorial Decision: Revise Minor
05 Jun 20201st Revision Received
05 Jun 2020Submission Checks Completed
05 Jun 2020Assigned to Editor
08 Jun 2020Reviewer(s) Assigned
08 Jun 2020Review(s) Completed, Editorial Evaluation Pending
08 Jun 2020Editorial Decision: Accept
24 Jun 2020Published in International Journal of Quantum Chemistry. 10.1002/qua.26372