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\begin{document}

\title{Bronchopulmonary dysplasia: incidence and severity in a cohort of
premature infants born at high altitude.}



\author[1]{Jefferson Buendia}%
\author[2]{Cristian Ramieez}%
\author[2]{Dione Benjumea}%
\affil[1]{University of Antioquia}%
\affil[2]{UNIREMINGTON Facultad de Ciencias de la Salud}%


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  \date{May 05, 2024}


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\begin{abstract}
Background: Bronchopulmonary dysplasia (BPD) is the most common cause of
chronic lung disease in children born prematurely. There is little
information about the epidemiology and severity of BPD places with high
altitude. This study aimed to evaluate the frequency of BPD severity
levels and the associated risk factors with severity in a cohort of
preterm newborns [?]34 weeks of gestational age born in Rionegro, Colombia
Materials and methods: We carried out a retrospective analytical cohort
of preterm newborns without major malformations from Rionegro, Colombia
between 2011-2018 admitted to neonatal intensive unit at high altitude
(2200m above sea level). The main outcomes were the incidence and
severity of bronchopulmonary dysplasia. Results: The bronchopulmonary
dysplasia incidence was 25.7\% (95\% CI, 21.6-29.9). Bronchopulmonary
dysplasia was moderate in 62.1\% of patients and severe in 26.7\%. The
most frequent complications were sepsis (62.1\%), hyaline membrane
disease (59.5\%), and pneumonia (26.7\%). After modeling regression
analysis, and force in the model the variable gestational age at birth,
the final variables associated with BPD severity levels were: duration
of oxygen therapy and pulmonary hypertension. Conclusion: The incidence
of BPD was higher and similar to cities with higher altitudes. In our
population, the variables associated with BPD severity levels were:
duration of oxygen therapy and pulmonary hypertension. It is necessary
to increase the awareness of risk factors, the effect of clinical
practices, and early recognition of bronchopulmonary dysplasia to reduce
morbidity in patients with this pathology.%
\end{abstract}%



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