Figure 7. In vivo assessment of PEG-FGF2 conjugates on skin wound healing. (A ) Representative images of wounds in mice after treatment with FGF2, compound 5 , 6 ,7 and PBS at day 0, 3, 5 or 7 post-wounding. (B ) The calculated wound closure rates in each group at the indicated time points. **P < 0.01,***P < 0.001 vs. control group;#P < 0.05 vs. FGF2 group. (C ) H&E histology of representative wound sections at day 7 after surgery. The wound margin is indicated by red dashed line. Scale bar = 500 μm. Masson’s trichrome staining of wound tissues in (D ) and the percentage of relative collagen areas in (E ). *P < 0.05,***P < 0.001 vs. control group;##P < 0.01 vs. FGF2 group. All values displayed are means ± SEM of 5 independent experiments.