Key Results
Compared with native FGF2, all PEG-FGF2 conjugates exhibited significantly improved stability in plasma and wound fluid. Compound6 more effectively promoted proliferation and migration in HDFs and HUVECs than FGF2, and exhibited excellent angiogenesis and wound healing activity in vivo . However, conjugates with the PEGylated sites near the receptor and heparin binding regions showed some reduction in bioactivity, with a greater loss of bioactivity for protein with site near the heparin binding domain.