Key Results
Compared with native FGF2, all PEG-FGF2 conjugates exhibited
significantly improved stability in plasma and wound fluid. Compound6 more effectively promoted proliferation and migration in HDFs
and HUVECs than FGF2, and exhibited excellent angiogenesis and wound
healing activity in vivo . However, conjugates with the PEGylated
sites near the receptor and heparin binding regions showed some
reduction in bioactivity, with a greater loss of bioactivity for protein
with site near the heparin binding domain.