Figure 7. In vivo assessment of PEG-FGF2 conjugates on
skin wound healing. (A ) Representative images of wounds in
mice after treatment with FGF2, compound 5 , 6 ,7 and PBS at day 0, 3, 5 or 7 post-wounding. (B ) The
calculated wound closure rates in each group at the indicated time
points. **P < 0.01,***P < 0.001 vs. control group;#P < 0.05 vs. FGF2 group.
(C ) H&E histology of representative wound sections at day 7
after surgery. The wound margin is indicated by red dashed line. Scale
bar = 500 μm. Masson’s trichrome staining of wound tissues in
(D ) and the percentage of relative collagen areas in
(E ). *P < 0.05,***P < 0.001 vs. control group;##P < 0.01 vs. FGF2 group. All
values displayed are means ± SEM of 5 independent experiments.