LIMITATIONS
This paper summarizes and analyzes the results of pathological immunohistochemistry in patients with previous surgery, so the sample size is small, and the detection of immunohistochemical indicators has certain limitations, and a more comprehensive comparative analysis cannot be undertaken. Postoperative adjuvant treatment was governed by the patients’ consent, so there is no analysis of the combination of immunohistochemical findings and the efficacy of clinical treatment. We shall continue this line of study in subsequent more targeted research. This paper only describes and analyzes the existing data, hoping to provide ideas for the future in-depth study of head and neck mucosal melanoma.
In conclusion, the analysis of local tumor markers will contribute to a deeper understanding of the characteristics of mucosal melanoma. The correlation between CD8 expression and PD-L1 expression in tumor tissue also indicates the significance of effector T cell infiltration in the tumor immune microenvironment and its role in the prognosis of patients, but further research is required. We need to expand the sample size to verify our conclusions on the incidence rate of lower head and neck mucosa melanoma.
Conflicts of interest :There are no conflicts of interest to report
Data Availability Statement :The data that support the findings of this study are available on request from corresponding author.