The suprachiasmatic nucleus (SCN) (in the hypothalamus) and, the pineal gland, which synthesizes melatonin and serves as the main executor of the SCN are two priciple brain regions that govern circadian sleep/wake cycles. The SCN suppresses or stimulates the pineal synthesis of melatonin according to the light/dark cycle, leading to a decreased or increased tendency to sleep \cite{Dedeene2019}.    

Complementary and alternative medicine (CAM) approaches for the treatment of ALS

Withania somnifera (animal)
Huolingshengji Formula (HLSJ) Clinical 200 ml, p.o., 12 weeks
Dihuang Yinzi (DHYZ):  Clinical Decoction, p.o., twice daily, 12 years Dihuang Yinzi, a Classical Chinese Herbal Prescription, for Amyotrophic Lateral Sclerosis: A 12-Year Follow-up Case Report(Cai & Yang, 2019)⁠
Berberine may have therapeutic value in ALS. Berberine is an mTOR inhibitor that increases autophagy. As autophagy is the major mechanism by which pathogenic TDP-43 aggregates are removed from the cell, it has been proposed as a possible target for ALS. (Chang et al., 2016)