What this study adds :
- This Chronic toxicity study reveals about the maximum dose level of
100 mg/kg body weight was found to be safe and it doesn’t produce any
toxic effects related to our drug over the animal model.
- Hence our study ensures Urai mathirai was found to be safe upto 100
mg/kg body weight.
INTRODUCTION
Traditional Systems of medicines are playing a key role in meeting the
global health care needs. India has different recognized systems of
medicine. They are Ayurveda, Siddha, Unani, Yoga, Naturopathy
Homoeopathy and Sowa Rigpa. Among them Siddha is the unique system of
medicine which is originated from Tamil nadu and has its origins in
Tamil language. Literally the word “Siddha” means “established
truth”. Siddha system of medicine was claimed to alleviate the root
cause of the diseases by maintaining the ratio of Vatham, Pitham and
Kapham. The origin of the Siddha system of medicine is attributed
from ancient saint called Siddhars(1).
Urai Mathirai is a drug used for the past three decades in the
form of long finger size bullets which are rubbed and administered
through breast milk with children’s to improve immunity to get free from
health hazards such as frequent respiratory infections /gastrointestinal
infections and anorexia. For global acceptance, this system of medicine
should undergo scientific validation, i.e., upgrading the one of the
levels is safety of the dose(2).
The acute and sub acute toxicity of the Siddha herbal formulation
urai mathirai was administered orally at a dose of 10, 50 and100
mg/kg.b.wt for 28 days does not showed any toxicity effect in wistar
rats.
Hence the present study was performed to evaluate the chronic toxicity
of the Siddha herbal formulation Urai Mathirai in
experimental wistar rats. Through this study the safety of this herbal
drug can be established for the clinical use of this traditional
formulation among the children’s to improve immunity.