Insulin Sensitizers
Metformin is a biguanide hypoglycemic drug that improves insulin sensitivity and decreases insulin levels which corrects ovarian and functional adrenal hyperandrogenism in PCOS (60). It is effective as adjunct therapy in the treatment of moderate-to-severe acne (61). Initial dose is 850 mg and may titrate up to 2,000 mg daily, and it should be discontinued in 6 months if no improvement is seen (62).