INTRODUCTION
Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy that affects 8–13% of reproductive age women (1). it is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries (2). These women have a higher incidence of developing complications such as type II diabetes, obesity, hypertension, dyslipidemia, and cardiovascular system diseases(3). Moreover, PCOS has a psychological impact with increased depression and anxiety that can result in worsening of quality of life for these patients (4). The exact mechanism underlying PCOS is unclear (5). The genetic contribution to PCOS remains uncertain, and no particular environmental factor has been identified as causing PCOS (6). Women with PCOS is characterized by high plasma level of ovarian and adrenal androgens, abnormal gonadotropin secretion, reduced serum levels of sex hormone-binding globulin (SHBG), and often high serum level insulin (7), as a result of insulin resistance (8). Obesity is a comorbidity that may intensify the effects of PCOS (9).