Flutamide
Flutamide is an anti-androgenic that blocks androgens by competitive
inhibition of receptors, reducing androgen synthesis (50). A combination
of flutamide and COCs improved acne by 80% (35). Flutamide at low
dosage of 62.5 mg daily or 1 mg/kg/day seems to be a safe and effective
for treating acne in women (51). Side effects include breast tenderness,
gastrointestinal upset, insomnia, and fatigue (52, 53).