Conclusions
Acne is common in patients with PCOS. Hormonal contraceptives are
first-line therapy for treating acne associated with PCOS and can be
used in conjunction with standard topiĀcal acne therapy or as
monotherapy. Spironolactone, oral antibiotics, and metformin can be
either added as second-line medications when hormonal therapies alone
are insufficient. Isotretinoin can be considered when acne is severe and
refractory to COCs, oral antibiotics, and spironolactone.