Conclusions
Acne is common in patients with PCOS. Hormonal contraceptives are first-line therapy for treating acne associated with PCOS and can be used in conjunction with standard topiĀ­cal acne therapy or as monotherapy. Spironolactone, oral antibiotics, and metformin can be either added as second-line medications when hormonal therapies alone are insufficient. Isotretinoin can be considered when acne is severe and refractory to COCs, oral antibiotics, and spironolactone.