Results:
1450 patients completed the smoking question; 219 controls, 546 CRS
participants without nasal polyps (CRSsNP) and 685 participants with CRS
and nasal polyps (CRSwNPs+). The mean age was similar with a greater
female preponderance in the control group and male in the CRSwNp group.
The greatest number of active smokers was found amongst control
participants (15%) with lower rate of smokers in both CRSwNPs+ (9.9%)
and CRSsNPs patients (13.9%) respectively (p=0.03). We found a
significant difference in the mean difference in SNOT-22 scores between
active smokers and non-smokers for both CRS phenotypes
(p<0.001) on Analysis of Variance. In both CRS subgroups
active smokers had significantly worse SNOT-22 scores than non-smokers
by a mean magnitude of 10 points. Non smokers also demonstrated a higher
percentage of surgical procedures (one or more) although this was not
statistically different (p=0.098).