Importance:
The deleterious impact of smoking on the respiratory tract is well known, however the relationship between smoking and chronic rhinosinusitis (CRS) has not been well characterised.
Objective: We sought to analyse whether active smoking was a risk factor for CRS and whether it has an impact on disease specific quality of life.
Design: Sub-analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES), a prospective, questionnaire-based case-control study conducted between October 2007 and September 2013.
Setting: Multicentre Case -Controlled across thirty UK Tertiary/ Secondary care sites.