In December 2019, with the outbreak of the unidentified pneumonia in Wuhan, China, a novel coronavirus was confirmed to be accountable for this disease and aroused great attention of the entire world. World Health Organization (WHO) officially named the novel coronavirus as SARS-CoV-2 and the unknown pneumonia as Corona Virus Disease (COVID-19). Up to April 13, 2020, there have been 83696 confirmed cases in China and 1837079 cases were totally confirmed in 209 countries outside of China with 119138 fatalities. The main manifestations are usually fever, cough, fatigues, breathlessness, and among others. To date, specific antiviral agents against the SARS-CoV-2 are not available. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. In this review, we detail current evidence and understanding of the etiology, epidemiology, clinical symptoms and current strategies on diagnosis, treatment, and prevention of COVID-19, which may provide a reference for future studies and help for the prevention and control of the COVID-19 epidemic.