Strengths and limitations
Our study has some limitations. Although we have spent time in clinical follow-up, there were still 75 women who were lost. Our study started in 2014. However, ES was underdeveloped and unavailable at that time and cause why all our cases of ES were collected in the last two years. Furthermore, we did not analyze all kinds of complications but only focused on PTB and IUD, which were most common. Neither did we have our own data of cordocentesis. The assessment of complication rate and diagnostic yield could be deficient. This study also has several strengths. The sample size in our cohort is the most abundant than previous ones so that our data could be more persuasive. Our study contributes unique and complete data since there are few previous larger studies analyzing late amniocentesis in the era of advanced technology which can improve prenatal and postnatal care and foster physical fitness among the population.