Our study has some limitations. Although we have spent time in clinical
follow-up, there were still 75 women who were lost. Our study started in
2014. However, ES was underdeveloped and unavailable at that time and
cause why all our cases of ES were collected in the last two years.
Furthermore, we did not analyze all kinds of complications but only
focused on PTB and IUD, which were most common. Neither did we have our
own data of cordocentesis. The assessment of complication rate and
diagnostic yield could be deficient.
This study also has several strengths. The sample size in our cohort is
the most abundant than previous ones so that our data could be more
persuasive. Our study contributes unique and complete data since there
are few previous larger studies analyzing late amniocentesis in the era
of advanced technology which can improve prenatal and postnatal care and
foster physical fitness among the population.