Main FindingsIn this retrospective analysis, we have the following findings. Firstly,
late detected abnormal ultrasound finding(s) becomes the most common
indication of late amniocentesis. Secondly, compared to cordocentesis,
complication rate of late amniocentesis is also competitive, while
88.7% of complications took place in fetuses with abnormal ultrasound
findings. Thirdly, compared to traditional karyotyping, both CMA and ES
achieve better diagnostic yield. Lastly, 86.4% of women who received
pathogenic genetic results terminated the pregnancies, and 24% of women
with normal genetic results still terminate the pregnancies owing to the
severe ultrasound findings.