Strengths and limitations
To our knowledge, this is the most comprehensive analysis to date of the
complement system in patients with PCOS, benefiting from careful
anthropometric and metabolic characterisation in addition to
measurements in the postprandial as well as the fasting state.
Nevertheless, whilst we intentionally sought to compare postprandial
complement activation kinetics in a carefully matched population of PCOS
subjects and controls, our study was limited by the absence of an
additional group of insulin-resistant women with PCOS. We were also
limited to a 4-hour study window after the fat challenge.