We aim to better understand the overriding plate deformation during the megathrust earthquake cycle. We estimate the spatial patterns of interseismic GNSS velocities in South America, Southeast Asia, and northern Japan and the associated uncertainties due to data gaps and velocity uncertainties. The interseismic velocities with respect to the overriding plate generally decrease with distance from the trench with a steep gradient up to a “hurdle”, beyond which the gradient is distinctly lower and velocities are small. The hurdle is located 500–1000 km away from the trench, for the trench-perpendicular velocity component, and either at the same distance or closer for the trench-parallel component. Significant coseismic displacements were observed beyond these hurdles during the 2010 Maule, 2004 Sumatra-Andaman, and 2011 Tohoku earthquakes. We hypothesize that both the interseismic hurdle and the coseismic response result from a mechanical contrast in the overriding plate. We test our hypothesis using physically consistent, generic, three-dimensional finite element models of the earthquake cycle. Our models show a response similar to the interseismic and coseismic observations for a compliant near-trench overriding plate and an at least 5 times stiffer overriding plate beyond the contrast. The model results suggest that hurdles are more prominently expressed in observations near strongly locked megathrusts. Previous studies inferred major tectonic or geological boundaries and seismological contrasts located close to the observed hurdles in the studied overriding plates. The compliance contrast probably results from thermal, compositional and thickness contrasts and might cause the observed focusing of smaller-scale deformation like backthrusting.