Case Presentation
The patient’s mother is a 29-year-old female who had two pregnancies and one delivery. The prenatal ultrasound examination was performed at 24 weeks of gestation, and the following were detected: the bilateral orbits of the fetus are asymmetric, the left eyeball is smaller than the right, the lens and vitreous body of the right eye have no obvious abnormalities, and there is a band-shaped hyperechoic area between the left eye lens and posterior wall of the eyeball with a funnel-shaped appearance with calcification (Figure 1a). Three-dimensional (3D) imaging shows that the left eyeball is smaller than the right, and the left vitreous has a band-shaped hyperechoic area (Figure 1b). Color blood flow imaging showed a band-shaped hyperechoic area, and the blood flow signal continued in the posterior papillary artery (Figure 1c). Prenatal ultrasonography was diagnosed as PHPV, but retinoblastoma is suspected. After communicating with the pregnant woman and her family, the pregnant woman requested to induce labor, and a baby girl was born. Postpartum ocular ultrasonography showed that an echogenic band with calcification extends from the vitreous to the posterior wall of the eyeball, which was consistent with prenatal ultrasonography (Figure S1a). Computed tomography showed a fibrous band between the left vitreous and posterior wall of the eyeball (Figure S1b). The left eyeball was smaller than the right (Figure S1c). The specialized ophthalmology examination showed that bilateral eyeballs were unequal in size, and the left eyeball showed a typical “white pupil” (Figure S2a, S2b). The pathological examination showed that the left eyeball was smaller than the right (Figure S2c). PHPV with retinoblastoma diagnosis was confirmed by the pathological examination, showing a retrolental connective fiber-vascular tissue, hyperplasia of blood vessels, retinal detachment and Rb were also observed (Figure S3a, S3b, S3c)