Introduction
Fetal persistent hyperplastic primary vitreous (PHPV) and retinoblastoma
(Rb) is rare congenital abnormal development of the vitreous
body1,2. According to related manifestations after
delivery, PHPV is clinically called “white pupil.” It mainly manifests
as vision loss and lens opacity and, in severe cases, as intravitreal
hemorrhage and eyeball atrophy. The disease is possibly isolated or
associated with congenital syndromes, such as Walker–Warburg syndrome
and Norrie disease. Rb is the most common intraocular malignancy of
childhood. The role of prenatal ultrasound screening for Rb has been
discussed3. Here, we present a case of persistent
primary hyperplasia vitreous diagnosed in the second trimester using
prenatal ultrasonography. An echogenic band with an irregular surface
was detected between the lens and the posterior wall of the left eye. No
other system abnormalities were present in the fetus.