Figure : COVID-19 pulmonary pathobiology is driven by dysregulation of angiotensin signaling (adapted from Sriram & Insel, 2020), which results in feedback between various cell types, leading to increased inflammation and cell death. These conditions are associated with increased Factor X activation, resulting in formation of thrombin, which has actions on platelets, endothelial cells, fibroblasts and alveolar epithelial cells inducing similar effects to those of ANG II in several cell types and promoting thrombosis, which exacerbates pulmonary injury along with that of other organs. ACE2: Angiotensin converting enzyme 2; ANG II: Angiotensin II; EMT: Epithelial-to-Mesenchymal transition.