Subgroup analysis
We also performed subgroup analysis to test the efficacy of individual drug treatments i.e AL, NAF, NIF, SIL, SILO, TAD, TAM. For SER there were 43 studies for these 7 comparisons and highest sucra values were obtained for NAF followed by SILO and TAD and least for NIF. For similar group, for SET with 27 studies and 7 comparisons, highest sucra values were obtained for SILO followed by SIL and TAD and least for NAF (supplementary table 5 and 6).
We also plotted cluster ranking plots for this network analysis presenting jointly the relative ranking of treatments (based on SUCRA percentages) for SER and SET (Figure 4A). Treatments occupying the upper right corner of this plot perform well for both the outcomes. Such as tadalafil and silodosin combination for the whole network and silodosin for the individual drug treatment analysis. (Figure 4A and 4B)