Stone expulsion rate (SER)
Compared to placebo all the treatment groups were more effective except NIF AND SIL (figure 3). Risk ratio (RR) of stone expulsion rate compared to placebo were highest for NAF-S [2.4 (1.6, 3.8)] followed by TADplusTAM-S [2.1 (1.3, 3.6)] and TADplusSILO [1.9 (1.3, 2.8)]. Rest of the risk ratios with their 95% confidence intervals (CI) have been provided in the table 2. SUCRA values were calculated to estimate the rank of efficacy according to stone expulsion rate (Supplementary Table 2). According to the SUCRA values obtained NAF-S had the highest rank followed by TADplusTAM-S and TADplusSILO. NIF had the lowest sucra value among treatment modalities.Global approaches for inconsistency models revealed consistency assumption for direct and indirect assumptions. Loop specific approach revealed 13 treatment loops without inconsistency (Supplementary figure 2). Node splitting revealed inconsistency for three comparisons i.e. C vs NAF, C vs. SILO and NAF vs. TAM.