Certainty of evidence
Risk of bias assessment as performed by study authors revealed 20 studies at high risk of bias, 10 at unclear risk of bias and 20 at low risk of bias. Most of the studies lacked placebo groups thus were at high risk of performance bias furthermore allocation to treatment groups was not blinded in many studies. None of the studies were at risk of attrition or reporting bias. Supplementary figure 3 depicts bar charts showing contribution of each study to the network estimate. Overall there were 27 mixed evidence and 78 indirect evidences and quality of evidence was ranked from very low to high and has been provided in supplementary table for primary outcome i.e. SER. Funnel plots showed mild asymmetry for the outcome SER however on regression analysis it was not significant furthermore funnel plot for SET was symmetrical (Supplementary figure 5 and 6)