The expression of PDIA4 is correlated with prognosis in glioma patients
Based on the findings that PDIA4 was aberrantly expressed in gliomas and showed strong relationships with histological grade and specific molecular subtype, we further studied the prognostic value of PDIA4 by Kaplan-Meier survival analysis with data obtained from TCGA and CGGA datasets. We found a marked correlation in the expression of PDIA4 and the poor prognosis of glioma patients (Figure 2A, B, p<0.001).Moreover, we validated this correlation in both GBM cohort and LGG cohort. Results indicated the high expression of PDIA4 was consistently correlated with poor patient outcomes in both the GBM group (Figure 2C, D) and LGG group (Figure 2E, F). To study whether PDIA4 is an independent prognostic factor in glioma, we also performed the Cox regression analysis with data obtained from TCGA and CGGA. In multivariate analysis, after adjusting many clinical factors, such as patient age, patient gender, WHO grade and IDH status, the results suggested the expression of PDIA4 was a strong predictor in patients with glioma (Table 1, Table 2).