Conclusion
We found that the frequency of uterine abnormality is more common in PCOS patients than normal population and this is correlated with maternal serum free testosterone levels.
Considering that PCOS is a transgenerational and transmissible disease, high frequency of uterine cavity abnormalities in PCOS patients can be attributed to increased, either direct effect of androgens to uterine development via WNT genes or indirect effect of AMH via increasing intrauterine GnRh Pulsatility - LH levels or reducing placental aromatase enzyme which is blocking maternal androgens, intrauterine androgens and downregulation of HOXA genes. (Figure-3)