Conclusion
We found that the frequency of uterine abnormality is more common in
PCOS patients than normal population and this is correlated with
maternal serum free testosterone levels.
Considering that PCOS is a transgenerational and transmissible disease,
high frequency of uterine cavity abnormalities in PCOS patients can be
attributed to increased, either direct effect of androgens to uterine
development via WNT genes or indirect effect of AMH via increasing
intrauterine GnRh Pulsatility - LH levels or reducing placental
aromatase enzyme which is blocking maternal androgens, intrauterine
androgens and downregulation of HOXA genes. (Figure-3)