Conclusion
Overall, in present study, we demonstrated that IV administration of E.
coli BW25113 strain bearing cardiac hormone expression construct could
result in tumor specific localization and subsequent hypoxia derived
expression of cardiac peptides. This resulted in suppression of tumor
growth, significant increase in survival rate and decreased expression
of MMP-9, VEGFR2, Ki-67 and CD31, all of which propose an antiangiogenic
and anti-metastatic activity for the proposed therapy.