Results
IV Administered bacteria bearing constructs could specifically localize
at tumor site and express cardiac peptides under hypoxic
conditions. Administration of
bacteria significantly enhanced survival rate, suppressed tumor
progression and lowered expression levels of MMP-9, VEGFR2, CD31and Ki67
as potent markers for angiogenesis, tumor proliferation and metastasis.
Furthermore, applied bacteria
resulted in significant reduction in the expression of IL-1β, IL-6,
GC-SF, IL-12 and TNF-α proinflammatory cytokines, whereas increasing
IL-10, IL-17A and INF-γ cytokines.