Conclusion
Overall, in present study, we demonstrated that IV administration of E. coli BW25113 strain bearing cardiac hormone expression construct could result in tumor specific localization and subsequent hypoxia derived expression of cardiac peptides. This resulted in suppression of tumor growth, significant increase in survival rate and decreased expression of MMP-9, VEGFR2, Ki-67 and CD31, all of which propose an antiangiogenic and anti-metastatic activity for the proposed therapy.