5. Conclusions
In summary, the development of more innovative diagnostic tests that
allow the early identification of women at risk for developing PE is a
recognized clinical need. The data obtained in this study are consistent
with the hypothesis that the accumulation of placental molecules within
GCF during early pregnancy are informative of the risk of developing PE
and could be surrogate markers of placental function. The practical
translation of these data to the clinical setting requires further
validation to determine its clinical implications.
Conflict of Interest statement: The authors have stated
explicitly that there are no conflicts of interest concerning this
manuscript. The funding organization(s) played no role in the study
design; in the collection, analysis, and interpretation of data; in the
writing of the report; or in the decision to submit the report for
publication.
Author contributions: All the authors have accepted
responsibility for the entire content of this submitted manuscript and
approved submission.
Details of ethics approval: The recruiting of pregnant women,
sample collection and analysis, were carried out with the approval of
Ethics Committees of Universidad de los Andes (FDF2016002) and Hospital
Sotero del Rio (RES019892).
Funding: The present study was supported by a Grant (FONDEF
IDeA ID16I10452) from the “Fund to Encourage Scientific and
Technological Development (FONDEF)” Ministry of Education. Government
of Chile”. Moneda 1375, Santiago de Chile. Dr. Romero was supported, in
part, by the Perinatology Research Branch, Division of Obstetrics and
Maternal-Fetal Medicine, Division of Intramural Research, Eunice
Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health, U.S. Department of Health
and Human Services (NICHD/NIH/DHHS); and, in part, with Federal funds
from NICHD/NIH/DHHS under Contract No. HHSN275201300006C.
Acknowledgements: We thank all the pregnant women for their
cooperation in our study. We also acknowledge to the members of the
Laboratory of Biology Reproduction of the Centre for Biomedical
Research. Universidad de Los Andes. Santiago, Chile.