Main Findings
The data obtained in the present study support the hypothesis that GCF-PLAP concentrations are significantly increased in asymptomatic women who develop PE later in pregnancy. Specifically, GCF-PLAP concentrations, measured at 11-14 weeks of gestation, were predictive of PE when combined with maternal systolic blood pressure in a multivariate predictive model. The performance of the predictive model was satisfactory, with an observed AUC of 0.77 (95% CI: 0.70 – 0.85) for all PE cases, 0.85 (95% CI: 0.81 – 0.93) for preterm PE, and 0.72 (95% CI: 0.58 - 0.82) for term PE. Bootstrap analysis confirmed the stability of our results.