Main Findings
The data obtained in the present study support the hypothesis that
GCF-PLAP concentrations are significantly increased in asymptomatic
women who develop PE later in pregnancy. Specifically, GCF-PLAP
concentrations, measured at 11-14 weeks of gestation, were predictive of
PE when combined with maternal systolic blood pressure in a multivariate
predictive model. The performance of the predictive model was
satisfactory, with an observed AUC of 0.77 (95% CI: 0.70 – 0.85) for
all PE cases, 0.85 (95% CI: 0.81 – 0.93) for preterm PE, and 0.72
(95% CI: 0.58 - 0.82) for term PE. Bootstrap analysis confirmed the
stability of our results.