Analysis of cytokines, chemokine’s and interleukins profiles of plasma of patients compared to CTRL
Several cytokines and chemokines were measured from healthy, before, during and after induction of chemotherapy lung cancer patients, CXCL8 shows a highly significant increase in lung cancer patients before induction of chemotherapy while slightly increase were shown in lung cancer patients during and after induction of chemotherapy when compared to healthy CTRL. Interestingly, IL-6 and IL-1 and shows a highly significant increase in lung cancer patients before and during induction of chemotherapy (100 and 13000 fold increase respectively) and no significant change in patients after induction of chemotherapy when compared to CTRL. According to CCL2, there is a highly significant increase in lung cancer patients before (250 fold) during and after induction of chemotherapy when compared to CTRL. CXCL10 shows a highly significant increase in lung cancer patients before and during the induction of chemotherapy when compared to CTRL. On the other hand IL-5, CCL11 and CCL4 show no significant change in their percentages in any group compared to the CTRL group fig 4.