Analysis of the fold change of granzyme B expression on T, NK and NKT cells in lung cancer patients compared to CTRL from before to after culture
when analyzing results in terms of fold changes of GzB expression on CD3, CD4, CD8, NK, NKT, NKCD4 and NKCD8 cells in lung cancer patients and CTRL before culture with after culture, all cell populations except the NK cells showed a marked increase in their expression levels of GzB upon activation in the newly diagnosed non-treated lung cancer group of patients. Similarly, these CD3, CD4, CD8, NKT, NKCD4 and NKCD8 cells all demonstrated a significant fold reduction during and after induction of chemotherapy when compared to CTRL. However, NK cell population where shown to be almost indifferent to the activation conditions, exhibiting no significant discrepancy in their fold change when compared to the CTRL fig 3B.