Nx (n = 11) Nx+4091 (n = 6) Hx (n = 9) Hx+4091 (n = 11) Hx+SU (n = 7) Hx+Su+4091 (n = 6)
BW (g) 23 ± 3 26 ± 5 24 ± 3 23 ± 3 25 ± 3 26 ± 2
HR (bpm) 455 ± 71 508 ± 71 455 ± 36 466 ± 34 519 ± 19 408 ± 52¶¶
LVSP (mmHg) 104 ± 11 96 ± 4 105 ± 6 97 ± 4 102 ± 21 98 ± 5
LVEDP (mmHg) 11 ± 3 6 ± 3 15 ± 3 11 ± 2 17 ± 10 8 ± 2
LVESV (uL) 40 ± 9 46 ± 11 35± 8 37± 11 42 ± 15 37 ± 12
LVEDV (uL) 55 ± 10 68± 10* 50 ± 9 58 ± 12 51 ± 13 57 ± 11
CI (mL/m2/min) 1092 ± 270 1495±142** 850 ± 138* 1413 ± 303§§§ 703 ± 76** 990 ± 208
Ea (mmHg/uL) 5.6 ± 1.0 3.8 ± 0.4*** 7.2 ± 1.0* 4.3 ± 0.9§§§ 9.2 ± 1.5***§ 4.5 ± 0.5¶¶¶
dP/dtmax (mmHg/s) 5841 ± 803 6385 ± 462 5559 ± 496 5567 ± 668 6021 ± 1114 5510 ± 1302
-dP/dtmin (mmHg/s) 5266±1029 5890 ± 570 4945 ± 788 4753 ± 553 4648 ± 1099 4504 ± 1302
dP/dVmax (mmHg/uL) 8.5 ± 2.8 6.5 ± 1.6 8.7 ± 2.8 6.1 ± 2.2§ 15.7 ± 4.2**§§ 7.0 ± 1.7¶¶
Tau (ms) 12 ± 4 8 ± 2* 13 ± 4 11 ± 3 12 ± 2 10 ± 2
Fulton’s index, RV/LV+S 0.23 ± 0.04 0.25 ± 0.04 0.39±0.08*** 0.20±0.03§§§ 0.39±0.03*** 0.29± 0.03¶¶¶
Ht (%) 46 ± 3 44 ± 2 60 ± 3*** 48 ± 6§§§ 59 ± 3*** 56 ± 4