|
Case 1 |
Case 2 |
Case
3 |
Age (yrs)/sex |
82/female |
89/female |
67/male |
DPP4-inhibitors
|
linagliptin→
teneligliptin
|
sitagliptin→
vildagliptin
|
alogliptin
|
Other drugs |
metformin 250mg |
amlodipine 5mg |
metoformin 500mg |
|
miglitol 75mg |
candesartan 1mg |
|
|
amlodipine 5mg |
|
|
|
candesartan 4mg |
|
|
|
loxoprofen 60mg |
|
|
|
etizolam 0.5mg |
|
|
Diabetic retinopathy |
none |
none |
none |
eGFR (ml/min/1.73m2)/UAE (mg/gCr) |
50.6/ - |
60.5/ - |
57.2/ 3.0 |
Comorbidity
|
Hypertension, cerebral infarction,
intestinal obstruction
|
Hypertension
|
Gastric ulcer, Hypertension,
Gallstones
|
Period of DPP-4 inhibitors administration
until onset of BP
|
16 months
|
38 months
|
6 months
|
anti-BP180 autoantibody |
328 U/mL |
3450 U/mL |
― |
erythema / blisters |
+/+ |
+/+ |
+/+ |
Eosinophil infiltration |
mild |
severe |
mild |
Relapse |
+ |
― |
― |
HLA(DQB1*03:01) |
― |
not examined |
+ |
Therapy for BP
|
prednisolone, minocycline, cyclosporine,
Steroid pulse therapy,
intravenous immunoglobulin therapy
|
prednisolone, tetracycline,
cyclosporine, niceritrol
|
prednisolone, tetracycline,
niceritrol, nicotinamide
|
Outcomes/
Cause
|
Death
Acute subdural hematoma
|
Death
Pulmonary metastasis?
|
Remission
|