Cladribine (0.1 µM) decreases the granularity of LPS-stimulated
microglia
The size and granularity of naïve and LPS-stimulated microglia treated
with CdA were investigated by flow cytometry (Figure 2 ). LPS
stimulation increased the SSC mean fluorescent intensity (MFI)
indicating increased cellular granularity (Figure 2A and B ). We
observed a trend towards reduced granularity of LPS-stimulated microglia
treated with 0.1 µM CdA (p=0.07), while CdA did not influence the
granularity of naïve microglia (Figure 2A and B ). No apparent
difference in cell size reflected by FSC MFI was observed
(Figure 2A and C ).