LPS and IL-4 increases the mRNA expression of the enzyme DCK
We examined the mRNA expression of DCK in naïve and activated microglia
treated with CdA. LPS stimulation increased the expression of DCK, while
IL-4 stimulation resulted in a similar trend compared to DMSO control
(p=0.08) (Figure 8A and B ). CdA (0.01-10 µM) did not change the
increased expression induced by LPS and IL-4 (Figure 8A and B ).
The expression of DCK was not affected by CdA (0.01-10 µM) in naïve
microglia either (data not shown).