The performance of mNGS and standard procedures for detecting
Aspergillosis
8 of 21 fungal pneumonia are Aspergillus pneumonia. Of the 8 cases, 7
cases were positive for mNGS, 5 cases were positive for
Galactomannan antigen detection
(GM test). 2 cases were positive for pathology, and only 1 case was
positive for routine culture. One case was positive for ROSE,
typical septate hyphae with
sharp-angled bifurcation could be found with ROSE (Fig. 3A). Although
the sensitivity of microbial culture was very low, the case missed by
mNGS happened to be detected by microbial culture, and GM test also was
positive (Table 2).