2.7 Statistical analysis
All statistic comparison was determined using SPSS 22.0 software (SPSS Inc., Chicago, IL, USA). Data multiple comparison was assessed by ANOVA following Turkey’s HSD multiple comparison test (P < 0.05, a, b, c, d and e). The statistical significance of the difference between two treatments was analyzed using a pairwise Student’s t test (‘*’, 0.01 < P < 0.05, ‘**’, 0.001 < P< 0.01, ‘***’, P < 0.001, ‘NS’, P> 0.05). The statistical significance of RNAi-mediated knockdown assays are analyzed by chi-square test (“*”, 0.01 < P < 0.05, “**”, 0.001 <P < 0.01, “***”, P < 0.001, ‘NS’,P > 0.05).